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Professor Allan D Struthers

Professor Allan Struthers

I am Professor of Cardiovascular Medicine. After graduating MB with Honours from Glasgow, I trained in Glasgow and London (Royal Postgraduate Medical School/Hammersmith Hospital). I am currently funded as PI by the BHF, the MRC, the CSO, Diabetes (UK) and the Chest, Heart & Stroke Association. In total I have had 29 different BHF grants including two 5 year BHF awards (one as PI). I have given 190 invited lectures (half abroad), published 380 papers and supervised 40 MD/PhDs. I focus on clinical cardiovascular research. One longstanding focus of interest has been B-type natriuretic peptide (BNP). I wrote one of the first two original papers published together in the Lancet which described the use of BNP to identify heart failure.  More recently, my group has shown that BNP can identify silent myocardial ischaemia which opens up the possibility of using BNP screening to identify those individuals whose first ever manifestation of their heart disease is sudden unexpected death. This tantalising possibility is being investigated with a 5 year BHF special grant (the 5P study). I also pioneered the use of spironolactone in heart failure. I was the first to show its cardiac benefits in man in 1995 which led to the 1999 RALES study where it reduced cardiac death, for which it is now in widespread use. My other main focus is in xanthine oxidase inhibitors where I have shown that high dose allopurinol prolongs the time to ST depression during exercise in angina patients, making it a completely new antianginal drug. Another related focus is in using cardiac MRI to examine novel ways to regress left ventricular hypertrophy (LVH). I am also working with Professor McMurdo to find novel ways to improve walking ability in the elderly. We have already shown that ACE inhibitors can achieve this and are exploring other novel approaches.

5 Key Papers:

Farquharson C, Butler R, Hill A, Belch JJF, Struthers AD. Allopurinol improves endothelial dysfunction in chronic heart failure. CIRCULATION 2002; 106: 221-226.

George J, Carr EA, Davies JI, Belch JJF, Struthers AD. High dose allopurinol improves endothelial function by profoundly reducing oxidative stress and not by lowering uric acid. CIRCULATION 2006, 114: 2508-2516.

Sumukadas D, Witham MD, Struthers AD, McMurdo M. Effect of perindopril on physical function in elderly people with functional impairment: a randomised controlled trial. CANADIAN MEDICAL ASSOCIATION JOURNAL 2007, 177(8): 867-874. Impact Factor of journal 7.2 This paper won the Bruce P Squires Award.

Sharman DC, Morris AD, Struthers AD. Gradual reactivation of vascular angiotensin I to Angiotensin II conversion during chronic ACE inhibitor therapy in diabetes mellitus. Diabetologia 2007, 50: 2061-2066.

Struthers AD, Lang CC. The potential to improve primary prevention in the future by using BNP/N-BNP as an indicator of silent “pancardiac” target organ damage: BNP/N-BNP could become for the heart what microalbuminuria is for the kidneys. European Heart Journal 2007, 28: 1678-1682.

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Last modified: 28 January 2014   2007 The University of Edinburgh