| Professor Allan D Struthers
am Professor of Cardiovascular Medicine. After graduating MB with
Honours from Glasgow, I trained in Glasgow and London (Royal
Postgraduate Medical School/Hammersmith Hospital). I am currently
funded as PI by the BHF, the MRC, the CSO, Diabetes (UK) and the Chest,
Heart & Stroke Association. In total I have had 29 different BHF
grants including two 5 year BHF awards (one as PI). I have given 190
invited lectures (half abroad), published 380 papers and
supervised 40 MD/PhDs. I focus on clinical cardiovascular research. One
longstanding focus of interest has been B-type natriuretic peptide
(BNP). I wrote one of the first two original papers published together
in the Lancet which described the use of BNP to identify heart failure.
More recently, my group has shown that BNP can identify silent
myocardial ischaemia which opens up the possibility of using BNP
screening to identify those individuals whose first ever manifestation
of their heart disease is sudden unexpected death. This tantalising
possibility is being investigated with a 5 year BHF special grant (the
5P study). I also pioneered the use of spironolactone in heart failure.
I was the first to show its cardiac benefits in man in 1995 which led
to the 1999 RALES study where it reduced cardiac death, for which it is
now in widespread use. My other main focus is in xanthine oxidase
inhibitors where I have shown that high dose allopurinol prolongs the
time to ST depression during exercise in angina patients, making it a
completely new antianginal drug. Another related focus is in using
cardiac MRI to examine novel ways to regress left ventricular
hypertrophy (LVH). I am also working with Professor McMurdo to find
novel ways to improve walking ability in the elderly. We have already
shown that ACE inhibitors can achieve this and are exploring other
5 Key Papers:
Farquharson C, Butler R, Hill A, Belch JJF, Struthers AD. Allopurinol improves endothelial dysfunction in chronic heart failure. CIRCULATION 2002; 106: 221-226.
George J, Carr EA, Davies JI, Belch JJF, Struthers AD.
High dose allopurinol improves endothelial function by profoundly
reducing oxidative stress and not by lowering uric acid. CIRCULATION
2006, 114: 2508-2516.
Sumukadas D, Witham MD, Struthers AD,
McMurdo M. Effect of perindopril on physical function in elderly people
with functional impairment: a randomised controlled trial. CANADIAN
MEDICAL ASSOCIATION JOURNAL 2007, 177(8): 867-874. Impact Factor of
journal 7.2 This paper won the Bruce P Squires Award.
Sharman DC, Morris AD, Struthers AD.
Gradual reactivation of vascular angiotensin I to Angiotensin II
conversion during chronic ACE inhibitor therapy in diabetes mellitus.
Diabetologia 2007, 50: 2061-2066.
Lang CC. The potential to improve primary prevention in the future by
using BNP/N-BNP as an indicator of silent “pancardiac” target organ
damage: BNP/N-BNP could become for the heart what microalbuminuria is
for the kidneys. European Heart Journal 2007, 28: 1678-1682.