| Dr Rory McCrimmon
Rory McCrimmon underwent his basic medical training at the
University of Edinburgh and completed his clinical training in the
South-East of Scotland before becoming an NHS Consultant Physician at
University Hospital Aintree in 2000. In 2002, he left his NHS position
and joined the faculty at Yale University to further develop his basic
research in glucose-sensing mechanisms. In 2009 he returned to the UK
to join the University of Dundee and is currently a Clinical Reader in
Dr McCrimmon’s Laboratory at Yale established roles for the SUR-1
selective KATP channel, AMP-activated protein kinase and Urocortin 3 in
the ventromedial hypothalamus, a key glucose-sensing region, in the
mechanism through which acute hypoglycaemia is detected and a glucose
counterregulatory hormone response initiated. In addition, the
McCrimmon laboratory recently identified a novel glucose sensing region
in the medial amygdalar nucleus that contributes to the detection of
acute hypoglycaemia. Evidence of the quality of this research programme
is reflected in the successful publication record of the McCrimmon
Laboratory, with recent manuscripts accepted by Cell Metabolism, the
Journal of Clinical Investigation and 15 papers in Diabetes, the
highest impact journal in the field of diabetes, in the last 6 years.
Since arriving in Dundee, in addition to establishing his own research
laboratory, Dr McCrimmon has been instrumental in developing a mouse
metabolic phenotyping core, arguably one of the first of its kind in
the UK. The infrastructure for this facility is now in place thanks to
a successful application for core funding from the Wolfson Trust and
will represent a major resource for local and national investigators in
the future. The McCrimmon Laboratory uses a number of techniques to
study the central regulation of glucose metabolism from hypothalamic
neuronal cell culture models to human studies providing a rich
environment for translational research.
Current Laboratory funding is from the JDRF, EFSD, MRC, NIH, Tenovus and Anonymous Trust.
5 Key Papers:
Zhou L, Podolsky N, Sang Z, Ding Y, Fan X, Tong Q, Levin B, McCrimmon RJ.
Themedial amygdalar nucleus: A novel glucose-sensing region that
modulates thecounterregulatory response to hypoglycemia. Diabetes 59:
McCrimmon RJ, Sherwin RS. Hypoglycemia in type 1 diabetes. Diabetes 59: 2333-2339, 2010
Fan X, Ding Y, Cheng H, Gram DX, Sherwin RS, McCrimmon RJ.
Amplified hormonal counterregulatory responses to hypoglycemia in rats
following systemic delivery of a SUR-1-selective potassium channel
opener. Diabetes 58: 448-52, 2009
Margaret Shaw, XiaoningFan, Haiying Cheng, Yuyan Ding, Monica C Vella,
Ligang Zhou, Ewan McNay, Robert S Sherwin. Key role for AMP-activated
protein kinase in regulating counterregulatory responses to acute
hypoglycemia. Diabetes 57: 444-450, 2008
McCrimmon RJ, Song
Z, Cheng H, McNay EC, Weikart-Yeckel C, Fan X, Routh V, Sherwin RS.
Corticotrophin releasing factor receptors within the ventromedial
hypothalamus regulate hypoglycemia-induced hormonal counterregulation.
Journal of Clinical Investigation 116: 1723-1730, 2006