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Dr Rory McCrimmon

Dr Rory McCrimmon

Rory McCrimmon underwent his basic medical training at the University of Edinburgh and completed his clinical training in the South-East of Scotland before becoming an NHS Consultant Physician at University Hospital Aintree in 2000. In 2002, he left his NHS position and joined the faculty at Yale University to further develop his basic research in glucose-sensing mechanisms. In 2009 he returned to the UK to join the University of Dundee and is currently a Clinical Reader in Translational Medicine.

Dr McCrimmon’s Laboratory at Yale established roles for the SUR-1 selective KATP channel, AMP-activated protein kinase and Urocortin 3 in the ventromedial hypothalamus, a key glucose-sensing region, in the mechanism through which acute hypoglycaemia is detected and a glucose counterregulatory hormone response initiated. In addition, the McCrimmon laboratory recently identified a novel glucose sensing region in the medial amygdalar nucleus that contributes to the detection of acute hypoglycaemia. Evidence of the quality of this research programme is reflected in the successful publication record of the McCrimmon Laboratory, with recent manuscripts accepted by Cell Metabolism, the Journal of Clinical Investigation and 15 papers in Diabetes, the highest impact journal in the field of diabetes, in the last 6 years.

Since arriving in Dundee, in addition to establishing his own research laboratory, Dr McCrimmon has been instrumental in developing a mouse metabolic phenotyping core, arguably one of the first of its kind in the UK. The infrastructure for this facility is now in place thanks to a successful application for core funding from the Wolfson Trust and will represent a major resource for local and national investigators in the future. The McCrimmon Laboratory uses a number of techniques to study the central regulation of glucose metabolism from hypothalamic neuronal cell culture models to human studies providing a rich environment for translational research.

Current Laboratory funding is from the JDRF, EFSD, MRC, NIH, Tenovus and Anonymous Trust.

5 Key Papers:

Zhou L, Podolsky N, Sang Z, Ding Y, Fan X, Tong Q, Levin B, McCrimmon RJ. Themedial amygdalar nucleus: A novel glucose-sensing region that modulates thecounterregulatory response to hypoglycemia. Diabetes 59: 2646-2652, 2010

McCrimmon RJ, Sherwin RS. Hypoglycemia in type 1 diabetes. Diabetes 59: 2333-2339, 2010

Fan X, Ding Y, Cheng H, Gram DX, Sherwin RS, McCrimmon RJ. Amplified hormonal counterregulatory responses to hypoglycemia in rats following systemic delivery of a SUR-1-selective potassium channel opener. Diabetes 58: 448-52, 2009

McCrimmon RJ, Margaret Shaw, XiaoningFan, Haiying Cheng, Yuyan Ding, Monica C Vella, Ligang Zhou, Ewan McNay, Robert S Sherwin. Key role for AMP-activated protein kinase in regulating counterregulatory responses to acute hypoglycemia. Diabetes 57: 444-450, 2008

McCrimmon RJ, Song Z, Cheng H, McNay EC, Weikart-Yeckel C, Fan X, Routh V, Sherwin RS. Corticotrophin releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation. Journal of Clinical Investigation 116: 1723-1730, 2006

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Last modified: 28 January 2014   2007 The University of Edinburgh